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KMID : 1225720200120010024
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Allergy, Asthma & Immunology Research : AAIR
2020 Volume.12 No. 1 p.24 ~ p.41
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Critical Points on the Use of Biologicals in Allergic Diseases and Asthma
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Agache Ioana
Cojanu Catalina
Laculiceanu Alexandru
Rogozea Liliana
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Abstract
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Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of disease endotypes to the effectiveness in real-world settings. We discuss here how these barriers can be overcome to facilitate the development of implementation science for allergic diseases and asthma.
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KEYWORD
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Biological products, phenotype, precision medicine, hypersensitivity, asthma
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